Wynton HPC - UCSF Research Computing at Scale #

Wynton HPC is a large, shared high-performance compute (HPC) cluster underlying UCSF’s Research Computing Capability. Funded and administered cooperatively by UCSF campus IT and key research groups, it is available to all UCSF researchers, and consists of different profiles suited to various biomedical and health science computing needs. Researchers can participate using the “co-op” model of resource contribution and sharing. The Wynton HPC environment grew as more users discovered it and more groups bought into the co-op model. Each contributing member brings more resources and compute power for everyone based on a fair-share model where contributors get higher access priority than non-contributing members. In addition, several UCSF centers have joined by contributing a large amount of their compute hardware to the cluster, e.g. Memory and Aging Center and QB3.

The Wynton HPC environment is available for free to all UCSF researchers. To join, please follow the instructions for requesting an account.

Please note, all Protected (P3 and P4) data will be removed by 2026-01-26. P4 data, which includes Protected Health Information (PHI), is prohibited as of 2025-07-08. Users with Wynton Protected account should prioritize removing remaining Protected data from Wynton. See “Wynton Protected” for UCSF’s P1-P4 classification standards and UCSF alternatives for storing Protected data.

Wynton’s Future #

Wynton HPC has been a vital resource for UCSF’s computational research, providing shared HPC capabilities to support diverse scientific projects. However, Wynton HPC is being gradually phased out to align with UCSF’s evolving research infrastructure strategy. While Wynton will remain operational for the near term, researchers are encouraged to plan for its eventual absorption into the Facility for Advanced Computing (FAC) and CoreHPC. UCSF is committed to supporting researchers during this transition and ensuring continued access to robust computational resources.

For more details on the upcoming changes, visit the Wynton Transition Keeping You Informed page.